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Mark Douglas Selected Research

duvelisib

11/2018Duvelisib, an oral dual PI3K-δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study.
11/2018Duvelisib, an oral dual PI3K-δ, γ inhibitor, shows clinical activity in indolent non-Hodgkin lymphoma in a phase 1 study.
1/2018Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies.
1/2018Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma.

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Mark Douglas Research Topics

Disease

4Neutropenia
11/2018 - 01/2018
3Infections
11/2021 - 08/2014
3Diarrhea
11/2018 - 01/2018
3Hematologic Neoplasms (Hematological Malignancy)
11/2018 - 01/2018
3Neoplasms (Cancer)
01/2018 - 12/2009
2Non-Hodgkin Lymphoma (Lymphosarcoma)
11/2018 - 01/2018
2Exanthema (Rash)
11/2018 - 01/2018
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
11/2018 - 01/2018
2T-Cell Lymphoma (Lymphoma, T Cell)
01/2018 - 01/2018
1Fibrosis (Cirrhosis)
11/2021
1Portal Hypertension
11/2021
1Anemia
01/2018
1Thrombocytopenia (Thrombopenia)
01/2018
1Pneumonia (Pneumonitis)
01/2018
1Hemangiosarcoma (Angiosarcoma)
10/2017
1Hepatitis C
12/2016
1Chronic Hepatitis C
08/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2014

Drug/Important Bio-Agent (IBA)

4duvelisibIBA
11/2018 - 01/2018
3Transaminases (Aminotransferases)IBA
11/2018 - 01/2018
2EnzymesIBA
11/2018 - 12/2009
2Alanine Transaminase (SGPT)IBA
01/2018 - 01/2018
2Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2018 - 01/2018
2InterferonsIBA
12/2016 - 08/2014
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2018
1RNA (Ribonucleic Acid)IBA
12/2016
1Programmed Cell Death 1 ReceptorIBA
11/2016
1AntibodiesIBA
11/2016
1Proteins (Proteins, Gene)FDA Link
11/2016
1B7-H1 AntigenIBA
11/2016
1Ribavirin (Virazole)FDA LinkGeneric
08/2014
1Interferon LambdaIBA
08/2014
1Drug CombinationsIBA
01/2014
1Antimitotic AgentsIBA
01/2014
1tanespimycin (17AAG)IBA
12/2009
1quinone (benzoquinone)IBA
12/2009
1hydroquinone (Esoterica)FDA Link
12/2009

Therapy/Procedure

2Therapeutics
10/2017 - 08/2014
1Liver Transplantation
11/2021
1Immunotherapy
11/2016